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Retatrutide can generate as much as 28.7% average weight loss at 68 weeks, compared to semaglutides lower percentage over approximately the same time period

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In patients with type 2 diabetes mellitus, treatment with semaglutide injection 1 mg resulted in reductions in glucose in terms of absolute change from baseline and relative reduction compared to placebo of 29 mg/dL (22%) for fasting glucose, 74 mg/dL (36%) for 2-hour postprandial glucose and 30 mg/dL (22%) for mean 24 hour glucose concentration

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Once-Weekly Semaglutide in Adolescents with Obesity (STEP TEENS)