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But originally, they were mostly for diabetes, is my understanding

Over time, this systematic underdosing adds up

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Progesterone's metabolite allopregnanolone acts on the same GABA-A receptors targeted by benzodiazepines when progesterone falls in perimenopause, this endogenous calming signal weakens, leaving the nervous system structurally less buffered against stress

We employ variants of the peptides GLP-1 and exendin-4 to explore the interplay between helical propensity near the agonist N-terminus and the ability to bind to and activate the receptor