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17 CB1 receptors are expressed in low amounts in normal liver, but they are significantly upregulated in stellate cells, hepatic vascular endothelial cells, and monocytes during hepatic pathology due to endocannabinoid system activation

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doi: 10.1164/rccm.201504-0780OC 207 BanDHuaSZhangWShenCMiaoXLiuW

For individuals with a Body Mass Index (BMI) of 30 or higher, or 27 and higher with a weight-related condition like hypertension, it serves as a tool to reduce caloric intake and improve metabolic function