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Although all the isoforms exhibit an LxxLL motif located at the C-terminal of the Forkhead DNA-binding domain, the surrounding regions diverge among them and this motif is not present in dFOXO or in daf16 in Drosophila melanogaster and C

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Upon addition of 1 (2.5 M) to the fractions in 2.0 mM CTAB media at pH 7.4 (50 mM phosphate buffer), significant fluorescence responses were observed in fractions F4 and F5 indicating the presence of native GSH in blood (Fig

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( F ) Viability of Pfa1 and xCT OE cells after 72 h of incubation with Tam (0.5 M) and Lipr (1 M), as measured with an ATP assay (left panel) and a PrestoBlue cell viability assay (right panel)