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Impaired responsiveness of GLP-1 to stimulate insulin secretion GLP-1-stimulated insulin secretion has an estimated heritability of 0.53, as demonstrated in twin studies [558]

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Both interventions target aspects of metabolic health, which has led to interest in whether their combination might enhance outcomes beyond what either achieves alone

It activates two receptor systems simultaneously: the GLP-1 receptor and the GIP receptor

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