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Among the factors thought to cause metabolic syndrome are a diet heavy in fat and carbohydrates and insufficient physical activity [8]

However, repeated overeating prevents weight loss and can trigger medication-related gastrointestinal erosion in rare cases

Additionally, we considered that as the manufacturing process is scaled up, other formulation or manufacturing changes are made, and new breakthroughs are made in biologic drug production the manufacturing cost might change significantly

Eligibility usually requires age 18 or older, a BMI of 30 or higher (or 27 or higher with a documented comorbidity), and no current GLP-1 medication

doi: 10.1016/j.bbrc.2014.03.004

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