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The advantage is obvious: no rounding needed at any standard dose
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Consequently, any skin irritation with basement membrane disruption can deteriorate melasma condition and also induce persistence or recurrence type of the disease (Kwon et al., 2016)
The article's dosing table adds that many patients see maximal benefit before the ceiling, so going further may add only marginal benefit while the side effect burden rises
PMID: 15699539
Multiple studies in our meta-analysis did not mention the depth of sedation and anesthesia used
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