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In addition, Ab#2_GLP1 retained similar human GLP-1R potency and maximum efficacy relative to the control GLP-1 analogue peptide Fc fusion molecule GLP-1-Fc(4) (Fig

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GLP-1 activates specific neurons in the hypothalamus that signal satiety (fullness) whilst inhibiting neurons that drive hunger

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Following a brain insult, microglia are the first responders, with reactive astrocytes subsequently becoming activated