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The second major characteristic used for comparison is the nature of the residue found before a very conserved cis -proline that is typical of proteins of the Trx superfamily

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Collectively, current clinical studies suggest that natural flavonoids, particularly quercetin, silymarin, EGCG, and grape seed proanthocyanidins, may exert therapeutic effects in both topical and systemic interventions for AD, with generally favorable safety profiles

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It binds and activates GHRH receptors on pituitary somatotrophs with high affinity, mimicking the action of endogenous GHRH