Strengths of STEP 5 include the high rates of adherence to treatment and completion of the trial (which contributed to consistency in findings between the two estimands)
The New England Journal of Medicine, 387 (3), 205-216
Based on this study, tirzepatide offered more effective blood sugar management and was superior to semaglutide in managing type 2 diabetes
Together, they may produce metabolic improvements that exceed what either compound achieves alone
This occurs because: Blood sugar monitoring becomes especially crucial during withdrawal to avoid hyperglycemia or the reappearance of diabetic symptoms like fatigue, blurred vision, or increased urination
However, regulatory timelines frequently shift due to additional data requests, safety reviews, or manufacturing considerations