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By abandoning epithelial absorption and substituting controlled tissue deposition, these technologies implicitly acknowledge the failure of classical oral pharmacology for proteins

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In AD, cerebrovascular dysfunction occurs earlier among E4 carriers (Veitch et al., 2019), which could lead to impairments in nutrient sensing and metabolite exchange between the brain and periphery, thereby negatively impacting brain bioenergetics by rendering brain areas of high energetic needs (e.g., the hippocampus) vulnerable to pathologies such as amyloid (Veitch et al., 2019

Standard therapies possess extensive, long-term safety data and profound cardiovascular benefits that make them the gold standard for initiating treatment