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According to Sciwind, the 'biased' mechanism differentiates it from other drugs in the class, and hypothetically at least can prolong its activity by preventing the drug from being internalised into cells and may reduce side effects like nausea

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MTHFR and the Methylation Cycle Normal role: MTHFR converts 5,10-methylene-tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), the active folate required for homocysteine methionine conversion

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6a and Extended Data Fig

This is one of the most important nutrients for healthy mitochondria and healthy energy production