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Recently, we reported that glycine deficiency led to impairment in the glycine conjugation pathway and resulted in a significant decrease in the elimination of endogenous and exogenous metabolites in individuals with severe obesity 11

Drug Alcohol Abuse 36 , 350356 (2010)

Wen, Z.-Y., Wei, Y.-F., Sun, Y.-H

[3] Normal free erythrocyte values in pregnancy are 2) [11] People with heavy menstrual bleeding [1] Frequent blood donors or with chronic blood loss [1-3] Gastrointestinal conditions (e.g., Crohns, IBS, parasites), including those that inhibit gastric acidity (e.g., antacid use, atrophic gastritis) and surgeries (e.g., bypass) [1-3] Patients with anemia of chronic disease [1] Patients with chronic kidney disease, especially with dialysis [2] Athletes and those with regular intense physical activity [3] (may have a 30% higher iron requirement [2] and some subpopulations of athletes may need up to 70% more iron [3]) Populations at risk for deficiency Deficiency signs and symptoms Brittle, spoon-shaped nails (koilonychia) [2,3] Sores at the corner of the mouth (angular stomatitis) [2,3] Taste bud atrophy [2] Sore tongue (glossitis) [2,3] Esophageal webs [3] Chronic gastritis [3] Microcytic hypochromic anemia [2,4] Impaired muscle aerobic capacity and lower exercise performance [3] Impaired work performance, slower nerve conduction, and impaired memory [3] Slower nerve conduction and impaired memory [3] In pregnancy, anemia (which may include IDA [2]) is associated higher risk of low birth weight,[1,2] premature birth,[1,2] and perinatal mortality [1-3] In infants and children, iron deficiency is related to a higher risk of impaired cognitive and behavioral development, [1-4] impaired psychomotor development, [3] developmental delays, [1,3] abnormal behavior patterns, [2] poor school performance, [2] and lower mental and motor test scores [3] The content provided is for informational purposes only and may not be an exhaustive list of potential interactions

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