When mitochondrial stress arises (from aging, nutrient excess, inflammation, environmental toxins, or psychological stress), ROS production outpaces antioxidant capacity, leading to electron leakage, superoxide accumulation, and oxidative damage to mitochondrial DNA, proteins, and membranes
Rondon G, Giralt S, Pereira M, Van Besien K, Mehra R, Champlin R, Andreeff M
Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Nakajima, A
309 METTL3 also represses autophagy in ischemic heart disease by methylating TFEB mRNA, decreasing its stability and nuclear translocation, thereby impairing lysosomal biogenesis and exacerbating myocardial injury during hypoxiareoxygenation
MEGA-PRESS may be a promising protocol, although the current MEGA-PRESS studies reporting brain GSH in MCI and AD were from a single research group, which may have artificially reduced heterogeneity
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