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Progressive loading is a fundamental aspect of rehabilitation, involving the gradual increase of mechanical stress to stimulate cellular responses and promote tissue adaptation

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Research in animal models has demonstrated that DSIP enhances enkephalin and endorphin signalling the bodys endogenous pain-modulating peptides and is associated with increased pain thresholds

BPA disrupts estrogen signaling and/or causes physiological effects at very low (nM) doses 12 that correspond to concentrations found in aquatic environments and wildlife 13