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Under the influence of GH, IGF-1 and IGFBP-3 can stimulate the proliferation of epiphyseal plate, promote the synthesis of collagen and sulfated mucopolysaccharide, participate in the regulation of protein metabolism, and hence promote growth and improve height [29]

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Radiographs and CT images reveal tissue destruction, poorly demarcated radiolucency, hypodense underlying bone, and occasional faint sunburst appearance resulting from mild calcifications along vessels radiating from the center of the tumor.[] MNTIs are biphasic tumors composed of small-cell and large-cell components that are arranged in a nest or cord arrangements set in a vascularized fibrous stroma.[ , ] The extent of surgical excision is debatable in the literature