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86,87 The lysine methyl transferase KMT DOT1L demethylates histone H3 at lysine 79 (H3K79me2) which promotes lineage-specific gene expression to regulate T H cell function

The mechanism is well characterized

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A live online exercise program for older adults improves depression and life-space mobility: a mixed-methods pilot randomized controlled trial

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They've optimized foundational interventions, sleep, nutrition, training, and stress management to the extent possible