Mitochondrial-mediated ROS cause oxidative damage to cellular structures, particularly mitochondrial DNA, somatic mutations, genome instability, inactivation of tumor suppressor genes, alterations in metabolic and signaling pathways with simultaneous activation of compensatory antioxidant mechanisms, all of which contribute to cell transformation and thus promote various types of cancer [42]
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High-dose perioperative atorvastatin and acute kidney injury following cardiac surgery: a randomized clinical trial
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As we age, NAD+ levels tend to decline, which may contribute to age-related diseases and a decrease in overall energy production
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