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Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins

When GLP-1 was incubated with 10% FBS, luciferase activity rapidly decreased

Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation

(April 2024)

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This paper reports a new class of masked nitrile oxide electrophiles as prodrugs for selectively targeting GPX4 in cancer cells