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Uncommon Warnings, Precautions, and Contraindications of Tirzepatide The FDA-approved labels for Mounjaro and Zepbound include several important warnings, precautions, and contraindications that clinicians must be aware of to ensure safe and appropriate use

The physician conversation covers dosing schedules and side effects, and frequently little else

The inclusion of glucagon agonism is why retatrutide produces such dramatically different outcomes in liver fat reduction compared to GLP-1 only compounds

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"Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes." New England Journal of Medicine