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Neuropsychopharmacology, 41(7), 19171928

[Abstract] Biochem Pharmacol

Applicable Across Sexes: While FDA approval is specific to women, clinical and anecdotal evidence suggest efficacy in men, particularly those inadequately responsive to PDE5 inhibitors

There is no published trial covering the specific combination at this duration, so the timeline draws on per-compound and analog data: Retatrutide TRIUMPH-4 reached 28.7% mean weight loss at 68 weeks at the 12 mg dose