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GLP-1 receptor agonists including semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and a growing pipeline of new entrants are being prescribed to tens of millions of Americans for weight loss and diabetes management, and they are fundamentally altering how, when, and how much people eat

The mechanisms underlying its hepatotoxic effects involve mitochondrial dysfunction, oxidative stress, and the inhibition of the bile salt export pump, resulting in the accumulation of toxic bile salts within hepatocytes [39]

The sulfonation reaction saturates at relatively modest doses, but the rates of the glucoronidation reaction and the rate of formation of NAPQI by the P450 reaction increase monotonically with dose

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Store reconstituted peptides refrigerated at 2 to 8C and use within 4 weeks

Nine compounds were significantly decreased and 8 compounds were significantly increased in the model group compared to the control group (Figure S3c)