doi: 10.1038/s41419-020-2381-8 128 HuangFMaGZhouXZhuXYuXDingFet al
48 Studies using Gasdermin D knockout models have demonstrated partial protection against hepatocyte loss, while pancaspase inhibitors failed to prevent cell death, although they reduced IL-1 production
This condition is very frequent, reaching a prevalence of approximately 9% in Caucasians (11.6 and 6.1% in males and females, respectively) [151], but differs geographically among various other populations [107]
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This reduction is key for inhibiting the enzymatic activity of 15-lipoxygenase, primarily by converting its non-heme Fe3+ to an inactive Fe2+ state
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