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Berberine is a compound found in parts of plants in the Berberidaceae family, including European barberry, goldenseal, and tree turmeric

The nausea typically peaks during the first two weeks and then gradually fades

10.1093/gerona/gly233 197 TangH

This route achieves tissue concentrations 10-20 times higher than topicals, making it the preferred method for researchers seeking maximum effect

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If you have diagnosed panic disorder, I would pick tirz, it is not a known documented interaction, but I have seen 2 or 3 people on this forum with panic episodes from reta, so while rare and not documented in the scientific literature as far as I know, it is possible it could trigger them in those with the right susceptibility