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Furthermore, cytoplasmic dsDNA levels are significantly increased in FLS from RA patients, causing upregulation of genes such as IL-6 , CXCL10 , TNF- , MMP-13 , IL-1 , and IL-8 via a cGAS-dependent mechanism that also disrupts joint homeostasis [22]

Effects of LC and TAU on the osteoblastic differentiation and mineralization of VSMCs Recently, it has been shown that vascular calcification in vivo has many features in common with bone mineralization