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At the cellular level, the defense against this oxidative damage is orchestrated by a complex network of antioxidants, with glutathione serving as the primary shield

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In multicellular organisms, Gsts display functional specificity to organs and tissues, underlying their necessity in growth and development 48,49,50,51

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It has been speculated that when peroxide activates ATM in vitro little autophosphorylation takes place and it may be partially dependent on complexing with the MRN complex recruited to DNA repair 51,76