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Consolidation of gains
Regular cycling with rest periods maintains benefits while minimizing concerns about continuous use
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However, this increase in BUN is also affected by other factors: the concomitant loss of HS at least in part explains the increase in BUN and fully explains the CLP-induced decrease in glomerular filtration rate (GFR) (98)
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Higher doses can stall the same process or even tip into toxicity over longer exposures, where free copper drifting loose from the complex starts driving oxidative damage
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