The naturally occurring peptide GHK (glycyl-L-histidyl-L-lysine), in its Cu-bound form, supports angiogenesis, remodeling, and tissue repair, has anti-inflammatory and antioxidant properties, and has been shown to improve cognitive performance in aging mice
H.DavidN.CampisiJ.ElisseeffJ
Baseline measurements were taken after an initial 5 min incubation with coelenterazine-h or NanoGlo-containing HBSS, after which cells were treated with either a vehicle (PBS) or the respective ligands
The study provides mechanistic insight into how BPC-157 modulates vascular tone and promotes endothelial cell migration, supporting its role in angiogenesis and cardiovascular protection
Funding The authors declare financial support was received for the publication of this article, which was covered by a grant from the Jeppe Juhl and wife Ovita Juhls Memorial Trust (to JF)
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