retatrutide phase 2 obesity nejm 2023 jastreboff GLP-1 Medications for Weight Loss: Semaglutide vs Tirzepatide vs Retat – Revolution Health & Wellness Original Article: Triple–Hormone-Receptor Agonist Retatrutide

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doi:10.5935/1518-0557.20190033 Ismail AM, Hamed AH, Saso S, Thabet HH

To reduce the development of obesity, cancer, diabetes, and cardiovascular diseases, WHO recommended a diet that includes an increased intake of fruits, vegetables, nuts, fish, and unsaturated fatty acids

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However, they differ significantly: semaglutide acts through GLP-1, tirzepatide through GIP and GLP-1, and retatrutide through GLP-1, GIP, and glucagon