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Nonetheless, the conclusions from these different studies raise the question of which, if any, redox couples are directly leading to cell death, i.e., is oxidation of thioredoxins or glutathione important, or are both perhaps simply markers of NADPH depletion

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LRRK2 is a protein kinase that is predominantly located in the mitochondrial outer membrane (West et al., 2005)

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however, the largest cluster included only two mice from the 5A-1MQ-treated group switched from WD to LD

Its potential role is supporting antioxidant defense during metabolic stress