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For injectable formulations, this can be complex because manufacturers must prove their products work identically to the original subcutaneous semaglutide formulations

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At the highest dose, 63% of participants achieved at least 20% body weight reduction versus 1.3% on placebo

In a clinical trial in pediatric patients aged 12 years and older, cholelithiasis was reported by 3.8% of WEGOVY-treated patients and 0% placebo-treated patients

Tirzepatide is a linear polypeptide of 39 amino acids that has been chemically modified by lipidation to improve its uptake into cells and its stability to metabolism