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Prescription costs have also risen 1315% on averagewith GLP-1s accounting for 20% of total prescription costs

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Weight loss at the 48-week mark had not yet plateaued in most dose groups, suggesting that longer treatment periods could produce even greater results

A more recent study using statistical parametric mapping suggested a reduced rate of DaT binding decline in exenatide-treated patients, particularly in the putamen and caudate, but results reached significance only at uncorrected thresholds ( p = 0.0034 and p = 0.0018, respectively) [32]

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This interest has shifted attention toward whether targeting brain circuits that regulate motivation and reward could help treat overeating and substance use disorders