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GLP-1 release is regulated primarily by glucose uptake into specialized cells called enteroendocrine GLP-1-producing cells (EECs of GLP-1) via sodium-coupled glucose transporters (SGLT)

Glycocalyx degradation can also lead to atelectasis

Patients often face this choice based on insurance coverage, availability, or costbut clinical factors matter equally

doi: 10.1056/NEJMoa1912196 95 van VollenhovenRAskanaseADBombackASBruceINCarrollADallEraMet al

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While optimizing diabetes control may indirectly support cognitive health through improved metabolic and vascular parameters, patients should discuss treatment decisions with their healthcare provider based on established evidence and individual health needs