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To determine an atomic-level understanding of S-coatomer interactions, we attempted co-crystallization of WD40 with either wild-type (1267Gly-Val- Lys -Leu- His -Tyr-Thr1273) or clientized (1267Gly-Val- Lys -Leu- His -Tyr-Glu1273) S tail heptapeptides

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Since the isolation of morphine in the early 19th century and introduction of heroin in 1898, medicinal chemistry efforts have yielded thousands of morphine analogs and structurally distinct opioids, resulting in a rich pharmacology (Corbett et al., 2006)

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Vedpriya Arya, [email protected] ORCID: Vedpriya Arya, orcid.org/0000-0001-7562-1731