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Despite these advances, PROTACs face inherent limitations, including high molecular weight, poor cell membrane permeability, and dependency on the cellular expression levels of the recruited CRBN or VHL E3 ligase 35

33,34 D 2 -like Receptors Overall, the pharmacological properties exhibited by the D 2 , D 3 and D 4 are similar to those exhibited by the originally defined D 2 receptor

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Journal of Neuroimmunology