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however, compensatory glycolysis and glucose uptake were observed in response to OXPHOS inhibition ( Investigators have paid special attention to del(11q)-positive CLL because the ATM gene found in that region plays a meaningful role in metabolism and ROS regulation ( We investigated the inhibition of glutaminase in CLL cell lines and treatment-nave primary CLL lymphocytes and the consequences for cell growth and survival

This creates a two-pronged stimulation, direct receptor binding plus cytokine-mediated amplification

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