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Semaglutide for weight loss Medically reviewed by Dr Kathryn Basford Last reviewed: 19 Jun 2026 Semaglutide is a type of medication called a glucagon-like peptide-1 (GLP-1) receptor agonist

Statistics and reproducibility The phase 2 clinical trial was powered to show a difference in proportions of 28% on primary endpoint MASH resolution and no worsening of fibrosis between once-daily semaglutide 0.4 mg (assumed 45% response) and placebo (assumed 17% response)

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Treatment persistence data further underscores this concern

If youve found that joint discomfort is limiting your ability to stay active, Semaglutide could be a transformative solution