E N D Presentation Transcript L-Carnitine Charisma Garcia NFSC 345 Introduction Background Purported Benefits Mechanism of Action Evidence of Benefits Conflicting Research Safety Concerns Professional Position L-Carnitine Essential for Energy Production Naturally Occurs in the Human Body Synthesized in the Liver & Kidneys Derived from the amino acid, Lysine Produces 11-34mg/day (Sufficient to meet all needs!) Dietary L-Carnitine Red meat, dairy, fish, wheat, asparagus, avocado Omnivorous diet: 20-200mg/day (~75% absorbed) No proof of Dietary need exists L-Carnitine as a Supplement Liquid form,Tablets & Capsules Typical Dose: 1000-6000 mg/day ~20% absorbed by the body Generally non-toxic Intended population: Athletes Dieters Purported Benefits Primary Systemic Carnitine Deficiency A recessive gene mutation Cardiovascular Disease Alzheimers Disease Chronic Fatigue In the Elderly Population In Cancer Patients Fat Loss No Evidence EXERCISE PERFORMANCE

Our view coming into this year is still pretty bullish for 2026
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in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis (44)
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