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The substance with the highest frequency of consumption was alcohol, followed by tobacco and marijuana (Table 1)

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This line derives from a cross between the Trkb- floxed ( Trkb lx ) line, as previously described 65 , and the BAC -Penk - cre tg/+ strain, carrying Cre recombinase under the control of the pre-pro-enkephalin promoter as previously described 13