L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH) [2]
Studies in humans have involved collection of induced sputum from the central airways (Table 11), sampling of the upper airways using nasal lavage and nasal epithelial lining fluid, and bronchoscopies with lavage (Table 13) to provide key insights into regional changes in immunological milieu
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Patients with chronic GI distress often notice meaningful improvement in bloating, regularity, and post-meal discomfort within the first 10 to 14 days
