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The prevailing model held that these drugs act directly on GLP-1 receptors in the brain, while our study provides evidence for an alternative pathway. For this study, the researchers used the weight-loss drug liraglutide, marketed under the brand names Victoza and Saxenda

Keenan Isoldi, Kathy PhD, RDN

They resist rapid breakdown and can cross biological barriers more efficiently

In native biological systems, endogenous amylin is co-secreted with insulin by pancreatic beta cells but possesses an exceptionally brief experimental half-life, subject to rapid renal clearance

Semaglutide (Rybelsus) is available in (daily) oral tablet form for T2DM

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