In fact, several studies have demonstrated that specific silencing of PNPLA3 in the liver, through antisense oligonucleotides (ASO), significantly improves various aspects of MASLD, including decreased hepatic steatosis, inflammation, and fibrosis 63
The treatment was given for 48 weeks (in addition to their usual medication) and then the participants were followed for another 12-weeks without exenatide (or placebo) in a washout period
38 GLP-1RAs increase microvascular blood flow in muscle tissue, enhance myocyte metabolism, inhibit muscle atrophy, and improve muscle mass and function
Neither comes as a daily pill, though oral versions are being developed
10.1126/scitranslmed.aan0972 Sci
Toutefois, aucune tude n'a encore t ralise auprs de ces groupes de population spcifiques