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GLP-1 agonists produce dramatic weight loss (averaging 15-20% total body weight) primarily through central appetite suppression, eliminating hunger and creating pharmaceutical satiety

8 They often start one to four days after discontinuing medication and last up to six weeks, sometimes lessening during that period

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One in five Americans report ever taking a GLP-1 for weight loss or a chronic condition, according to a 2025 poll

p=0.24), and heterogeneity was negligible ( I 2 =0%) (Fig

Fishers exact probability test was used to assess the number of dead and surviving rats