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Both have shown significant efficacy, with head-to-head data (SURPASS-2) suggesting potential advantages for tirzepatide in certain endpoints

N Engl J Med 385(10):896907 Gofron KK, Wasilewski A, Magorzewicz S (2025) Effects of GLP-1 analogues and agonists on the gut microbiota: a systematic review

If you gain the weight back, it comes back as fat

The goal is to move from interest to treatment without clinic visits or insurance steps

The other group received both HA and semaglutide

Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, Bonnet J, Butsch WS, Christensen S, Gianos E, Gulati M, Gupta A, Horn D, Kane RM, Saluja J, Sannidhi D, Stanford FC, Callahan EA