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IGF-1 LR3 binds to IGF receptors, particularly type-1 IGF receptors, to exert its biological effects within these complex signaling pathways

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In research models of accelerated senescence or cellular aging (e.g., replicative senescence in cell lines, organoid aging systems), the blend has been theorized as a possible probe to study whether re-stimulation of GH axis signaling mitigates markers of cellular agingsuch as senescence-associated -galactosidase, mitochondrial dysfunction, telomere attrition, or oxidative damage markers

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