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( Anaesthesia, 2021 ) report that the epidemiology of local anesthetic systemic toxicity (LAST) is shifting, with delayed onset increasingly common, a growing proportion of cases arising from fascial plane and field blocks, and more events occurring outside the operating room and involving non-anesthesiologists

Naloxegol treatment at 2 h post morphine injection resulted in significantly increased fecal output and small intestinal motility in mice expressing AAV-DIO-shMOR-EGFP compared to that of AAV-DIO-EGFP-expressing control mice (Fig

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95% CI: 0.160.40), and 75% lower odds of any SUD compared with non-users participants (OR = 0.25, 95% CI 0.220.30)

Lee YG, Park M, Jeong SH, et al