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Retatrutide addresses both sides: Reduced load on knees, hips, and spine from fat loss Lower inflammatory cytokines in and around joints Less inflammatory fat around weight-bearing structures Reduced oxidative stress that can damage cartilage over time Some individuals may therefore experience: Less joint stiffness Improved walking tolerance More comfortable physical activity, which reinforces metabolic benefits 2.7 Cognitive and Neurological Benefits GLP-1 receptor agonists have been studied for potential benefits in conditions like Alzheimers disease, Parkinsons disease, stroke recovery, and traumatic brain injury

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Carnitine supplementation during VPA therapy in high-risk patients is now recommended by some, especially by pediatricians [133]

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