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Acknowledgements This work was supported by the National Institutes of Health (R01 GM056414, to S.H.G.)

The authors described MC1R as a receptor with pleiotropic signaling capacity , noting that its activation has been associated with pathways involved in inflammatory modulation and cellular stress adaptation rather than melanogenesis alone

and initiation of appropriate preconception supplements and vaccinations

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Likelihood ratio tests were employed to compare differences between two groups, and Wald tests were utilized to compare differences between three or more groups

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