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Binds VPAC1 and VPAC2 receptors to reduce IL-6 and TNF-alpha production

These are the structural proteins that give skin its firmness and elasticity

Studies with transdermal forms did not show elevations of reduced glutathione either

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Nle1-dipeptide (Nle-Tyr) had a Ki of 1.00 10-6 M indicating a substantial decrease in binding efficacy [99]