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16 , e0010415 (2022)

Site Rotation Protocol Rotating injection sites prevents lipohypertrophy (fatty lumps under skin), reduces scar tissue formation, and maintains consistent absorption

Possible side effects include nausea, fatigue, or digestive discomfort

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

The right trial would be in people w ithout any cognitive impairmen t but at high-risk as defined by family history, high polygenic risk score, APOE4 carrier or homozygotes, high levels of p-Tau217 and other blood biomarkers

Reduced efficacy A biweekly dosing schedule may reduce the therapeutic effectiveness of semaglutide